The final stage of this route connects Azambuja to Santarém, crossing the fertile plains of the Ribatejo floodplain, marked by dikes, rural roads and irrigation canals. In its first kilometres, the path follows the Vala Real, an 18th-century canal built to control floods and facilitate river transport. The landscape alternates between farmland and small villages that preserve the traditional way of life along the river.

Between Reguengo and Valada stretch vineyards, orchards and fields of corn and tomatoes. Near the route, in Palhota, stand the wooden stilt houses, a symbol of the old fishing communities. Valada, a parish of the Cartaxo municipality, preserves the Church of Nossa Senhora do Ó, of medieval origin, and a popular riverside beach.

Further ahead, the route reaches Porto de Muge and the Rainha D. Amélia Bridge, built in 1904, near the Palace of the Dukes of Cadaval and the remains of a Roman bridge. The path continues through farmland, then between vineyards and farms until it reaches Santarém.

The ascent into the city is steep, via Calçada da Junqueira. Santarém retains its character as the capital of the floodplain, with a vast heritage that includes Gothic churches, convents and museums such as the Church of São João do Alporão, the Church of the Holy Miracle and the Convent of São Francisco.